Genetic progression of Barrett’s oesophagus to oesophageal adenocarcinoma
نویسندگان
چکیده
منابع مشابه
review of barrett’s oesophagus to oesophageal adenocarcinoma: new prospect
today’s knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between barrett’s disease and progression to adenocarcinoma. the incidence of this disease has been accelerated sharply in current decades since people life has changed. studies have been demonstrated that several potential factors including genetical and environmental ...
متن کاملReview of Barrett’s Oesophagus to Oesophageal Adenocarcinoma: New Prospect
physiological changes in epithelial form and function(1). It was a pre-malignant disease of oesophageal adenocarcinoma (OA) in which normal oesophageal epithelia were replaced by columnar epithelia at gastro-oesophgeal junction(2-8). The increasing incidence of BO and OA over the last two decades shows that it was becoming a major public health concern in developed countries such as the US, UK ...
متن کاملEpigenetic biomarkers in progression from non-dysplastic Barrett's oesophagus to oesophageal adenocarcinoma: a systematic review protocol
INTRODUCTION Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patient...
متن کاملDuodenal juice stimulates oesophageal stem cells to induce Barrett's oesophagus and oesophageal adenocarcinoma in rats.
the present study was performed to examine the sequential process of the development of Barrett's oesophagus (BE) and oesophageal adenocarcinoma (ADC) induced by duodeno-oesophageal reflux (DER) in rats. Total gastrectomy was performed in male Wistar rats weighing approximately 250 g followed by reconstruction with oesophago-jejunostomy, which causes unavoidable DER without exposure to exogenou...
متن کاملCirculating microRNAs as potential biomarkers to detect transformation of Barrett’s oesophagus to oesophageal adenocarcinoma
Objective Circulating microRNAs (miRNAs) are promising biomarkers for the early detection of cancers. This study aimed to address potential circulating miRNAs to monitor the progression from Barrett's oesophagus (BO) to oesophageal adenocarcinoma (OAC). Design We comprehensively analysed tissue and serum miRNA expression profiles of BO mice model (L2-interleukin-1β (IL-1β) mice) using microar...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2016
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2016.219